EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.3.78 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.3.78 | HUT-78 cell | - |
Homo sapiens | - |
3.1.3.78 | T-lymphocyte | - |
Homo sapiens | - |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.3.78 | IpgD | - |
Homo sapiens |
3.1.3.78 | PtdIns(4,5)P2 4-phosphatase | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.1.3.78 | additional information | phosphatidylinositol 5-phosphate may play a sensor function in setting the threshold of T-cell activation and contributing to maintain T-cell homeostasis | Homo sapiens |
3.1.3.78 | physiological function | PtdIns(4,5)P2 4-phosphatase expression induces Src kinase and Akt, but not ERK activation and enhances interleukin II promoter activity in T-cells. Expression of a PtdIns5P interacting domain, PH-Dok-5, blocks IpgD-induced T-cell activation and selective signaling molecules downstream of TCR triggering, evaluation, overview | Homo sapiens |